Localized information makes sense, but you'd also have to take in mind survival of the fittest. Bigger, faster wasteland critters would still want to eat cats, even if the humans of the east coast didn't commit cat genocide.
Point out any lore bits you noticed so far in Fallout 4,
-Vertibirds in Pre-war Boston
-Cats not being extinct
-Warning prior to bombings
-Many item/weapon redesigns
-Power armor everywhere
"Fallout 4 is also fully destructible. This gives players a whole new way to approach combat situations, as well as giving you more room to just blow stuff up for the sheer fun of it. Because, essentially, that’s what Fallout has always been about."
This kills the man.