Strange, i finished the game in TG mode. I had some crashes, and I have to admit they were frustrating especially when you nearly finished a mission, but it was possible.
I got exactly the same problem. I can confirm that it has nothing to do with the resoultion (out of range), nor the sound/speakers, nor with the DVD drive.
It comes somewhere from the pc, I would guess the mainboard, maybe the power supply, the graphics card or the harddrive (although I don't...