Unfortunately I don't use any performance mods (even the good ones like NVTF) because that would interfere a lot with my TTW testing. So I can't really tell you proper settings.
You should also disable "bSpinCriticalSections" in it if you're using New Vegas Heap Replacer (and you should, I don't remember if I suggested it to you before or not).
I can tell you also to set your max FPS in it to whatever one you want your game to run at (for example, setting it at 60 or 75 depending on your computer and preference).
You should also disable "bSpinCriticalSections" in it if you're using New Vegas Heap Replacer (and you should, I don't remember if I suggested it to you before or not).