The guards outside the Ghost Farm run up to you, but they don't tell you to "surrender or die" unless you initiate dialogue, so unless you click one by accident or they box you in, you can just leave.
I found some "marauders" near I think Broken Hills, who have "Error" as a combat taunt. Also, killing a slave-owning caravan owner shouldn't lower your karma.
Something weird happened with Marcus in BH. After getting all his jobs, offering to find the missing people for free, fixing the mine, and declining Jacob's request for help with the jailbreak:
If I tell Marcus about the dead people, I get the rifle -- but he also locks up Jacob and gives the appropriate floating text. I don't get the 2500 XP, though. I have no options to tell him about anything, and he'll join my party.
If I tell him about Jacob's plan, he locks them up, and I get the 2500 XP. I can then tell him about the bodies, and get the rifle -- but even if I don't, he'll join my party.
Does telling Harold about delivering the economic data have any lasting effect on your standing with him? He seemed genial enough when I left dialogue and spoke with him again.
Do I have to deal with the Brain to get the best ending for Gecko? I can get the holodisk from Gordon without the talisman, and going through all those tunnels is a pain in the ass.
The shopkeepers in SF keep their cash (including what you trade them) in their personal inventory. This is just too good a temptation to resist -- FIX IT PLEASE
