I've read about it couple days ago. My reaction was neutral. Either I'll watch one / two episodes or forget about it. By the time it'll be released (2022?) I don't think I'll be putting much attention to the whole Fallout franchise (except for Fallout 2 mods).
One thing Fallout was about is how humans deal with unknown. The Brotherhood, the Master, the Hub, the Vault 13 all were trying to figure it out what to do next in this unknown world, then we were tinfoiled by Fallout 2, then Bethesded. Fallout lost its true credo.
So my bet is on:
There is a Vault City or freshly opened Vault (not pure good, not pure evil). Our protagonist is trying to figure out what is the source of all this. Some politics (don't let the tribal get your job!), some action (shoot those super duper mutants boy!), some mercy (the ghouls were nice right from the beggining!). We get some stupid social experiment and the Enclave (tinfoil + tinfoil and the goverment is to blame). And in the end they lived happily ever after under... egh democracy?
And this time, he (or she) will be looking for his/hers lost uncle.