You can definitively confront him but you have to prove first that he is the poisoner by running analysis on the suspicious stimpak as well as see the security footage video. Also the quest needs to be accepted as well. And then you can confront him.
I had forgotten about checking security footage for the Brotherhood traitor questline, it's been a long time since I last did this. However, it may be impossible to complete now, Tibbets is kinda, uh, gone, and I remember you take Devon's head to a doctor there to analyze for the location of the Circle Of Steel hideout.
Why do Alexandra and Mark only have 50 max HP? This makes it incredibly easy for them to die during combat encounters compared to the Hanged Man, who has 139, and has made it with me through the entire game so far. (I know in the future it will be possible for companions to level and thus increase their max HP.) Something I wanted to mention about Alexandra though, it was very refreshing to have a voiced talking head finally! Very much looking forward to more of those. (Would love to hear the AI Joshua Graham voice for the Hanged Man lol)
The NCR troopers guarding the debris on The Rim don't react to the PC wearing power armor while the war is still ongoing.
Per your completable quest list, I had no idea the resolution of the NCR-Brotherhood war was possible. I haven't been able to secure a meeting with Governor Dodge, but I have done three caravan runs for Ailis McLafferty, who has let me in on her psycho plan to take over leadership of Hoover Dam, can I use her to broker peace between the two factions or, once you accept her plan, are you stuck on that path. (I saved before speaking with her so I loaded once I learned her plan.)
On that note, it doesn't seem like there's a nonviolent way to confront Ailis about her dealings with Devon.
Also, if you decline helping her, she tells you you have 24 hours to get out of town, but after dialogue ends, combat with the Crimson Caravan will be initiated immediately, same goes for if you tell her you will report her to the authorities. After winning the combat encounter, (which one police officer joined and I killed), the NCR troopers at the military HQ shot me on sight, so I assume you can't just defend yourself from Ailis and her cohorts and get away with it.
I tried to turn in the "Eliminate hostile mutants in the Scum Pits" quest to Farmer Dave, because I killed all the critters in both there and S-1-C, but there was no option to do so.
Isaac will not tell you the Brotherhood armory codes because he does not want to help the Brotherhood. He says that's his final word on the matter, but does this have to do with the settlement's reputation system, too?
This is a weird one, after applying your hunger system bugfix and getting the Strength enhancement surgery, the year went from 2259 to 2272.
The Hanged Man has disappeared. I told him to wait outside Mesa Verde as usual while I went to learn the Ciphers' schematics they carved into the walls, but I didn't know that would pass time. I guess if followers wait in one spot too long they disappear forever? I'm suffering from a Jet addiction that can't be cured, so I was using his inventory to help with the loss of Strength points... bye-bye, .223 minigun, gauss rifle, technical manual, and chemistry journals.
Speaking of followers, Beatrice immediately broke after recruiting her. She would participate in combat encounters, but could not be spoken to, and would not move outside combat, either. And, after bringing Mark to Bloomfield, he mysteriously disappeared and the Rusty Hooks all turned hostile.
The power armor disappearing bug also applies to the suit in the Brotherhood armory.
I am getting fruit with the message "Your tree bore a piece of fruit." as if I had the Bonsai perk, but I never took it.
Oh, one more thing, how do you find the guy with the space suit and the truck capable of transporting your rocket fuel? The walkthrough just says to explore the wasteland so I assume it's a random encounter, but is there a reliable way to find him?