I thought Pillars of Eternity was really fun and it was my very first isometric RPG since Fallout 2. The dialogue, the choices throughout the game, the combat, etc it was all really great. Replaying it was really daunting though because of how much stuff there is, especially with the DLCs. Come to think of it I technically never beat the game... Well I know what I'm doing during Christmas Break.
Tyranny is also a really great game. Short, sweet, and full of choices that makes replaying it with an almost completely different look entirely possible. I'm enjoying it a lot. Combat's a little glitchy right now but I'm sure some patches will fix that. I was able to beat it without much issue which is saying something considering how the "Obsidian only makes buggy games" meme is still going.
Honestly I hope their next big project (besides POE2) is a Vampire the Masquerade game. We've waited so long, and Paradox even owns White Wolf now! Obsidian even said in a recent interview that they already really want to make one, they just can't yet because something something legal problems. I hope whatever the issue is gets resolved soon. I don't even care if it's isometric, I just want a new VTM game damnit.