Bug report: Windows 7, got everything installed fine. Got through Arroyo, skipped most of Klamath, headed to the Den with a bunch of stolen goods. Run into first Kaga encounter (You weren't kidding when you said he was gonna be nasty), and a couple of things go wrong. First, during the dialog with Kaga, you can barter with him (1000$, 1xSuper Stimpak, 4xSpear), and he doesn't care. After doing that, I ran away - but once I got back to the world map and try to enter the Den, game crashes with memory cannot be read error. Restart game, try again, get Kaga encounter again - but this time, as I try to run away, when it gets to Kaga's turn, he vanishes and the game freezes hard. Had to switch users and then try to bring up task manager; before I switched users, I couldn't get the game to lose focus. It now occurs to me that I didn't try alt-F4, but still a nasty crash regardless.
Also, I forgot just how boring the first two hours of the game are.